Upon completion of this workshop, the attendee should be able to:

•Describe the important antimicrobial resistance mechanisms of problematic bacterial pathogens such as Gram-positives MRSA/CMRSA USA300, EMRSA-15, hVISA/VISA, VRE, and in Gram negatives resistance to Beta-lactamase resistance  such as MBL, ESBL, AMPC, KPC etc..

•Apply CLSI and CDS latest Standardised Guidelines to detect resistance antimicrobial agents in the laboratory in the light of evolving resistance in various organisms; and

•Understand the various phenotypic and molecular methods and approaches used to track the development of antibiotic resistance – epidemiology.

LOCATION

Faculty of Medicine. Infectious Diseases and Immunology Laboratory. Level 4 Classroom Blackburn Building, University of Sydney. Bus will take attendees from Darling Harbour to the University.

Lunch (Tea and Coffee breaks when required) will be provided at the venue and is included in the cost of registration.

PRELIMINARY PROGRAM

This full day workshop is divided into two parts:

Morning Session: Series of small lectures and updates from the experts

Afternoon Session: Hands on tutorials and practical demonstration with discussions. Notes will be provided to all attendees.

http://www.elmy.ee/public/files/Microsoft%20PowerPoint%20-%20EUCAST_Estonia_2009Gunnar%20II%20osa%20%5BCompatibility%20Mode%5D.pdf

http://www.tourhosts.com.au/live/racpcongress/PDF_files/ppt/TURNBRIDGE_John.pdf

 Prof: John Turnidge Adelaide  – South Australia

 Dr. John Merlino – ASM National Convener ASM – AIMS Conference NSW Sydney

http://www.alloccasionsgroup.com/upload/documents/AIMS/Power%20Points/1400%20Kay.pdf

By Ian Kay

http://www.alloccasionsgroup.com/upload/documents/AIMS/Power%20Points/1400%20Bell.pdf

By Jan Bell

 Dr. John Merlino – ASM National Convenor ASM – AIMS Conference Adelaide Convention Centre Australia

http://www.idsociety.org/Content.aspx?id=6252 

The development of antimicrobial agents (antibacterials, antivirals, antifungals and antiparasitics) to treat infections has been one of the most notable medical achievements of the past century.  These advances in medical care are threatened, however, by a natural phenomenon known as “antimicrobial resistance.” Antimicrobial resistance, whereby microbes mutate and become less susceptible to these “miracle drugs” over time, creates problems for infectious diseases physicians as they must work quickly to determine what drug will work on a patient’s infection.  Microbes’ ability to become resistant to antimicrobials not only impacts individual patients, but also can have devastating impacts on the general population as resistant microbes pass from one individual to another.

Worrisome recent examples of drug resistance include vancomycin-resistant Staphylococcus aureus (VRSA) and community-associated methicillin-resistant Staphylococcus aureus (MRSA). The emergence of VRSA is of great concern to clinicians and public health officials as vancomycin is typically the drug of last resort in treating S aureus and several other infections.  MRSA, in the recent past, only affected immune-compromised individuals and the elderly in hospital settings.  Now, it is occurring across the country in local communities—infecting healthy and strong individuals.

To preserve the effectiveness of antimicrobials, IDSA has adopted Principles and Strategies Intended to Limit the Impact of Antimicrobial Resistance.

Due to the increasing seriousness of this issue, IDSA also is working:

• to obtain appropriate funding for federal antimicrobial resistance efforts;
• with Congress to develop legislation to preserve antimicrobials’ effectiveness and to incentivize research and development of new classes of antimicrobials;
• with federal agencies to identify appropriate administrative activities;
• to monitor the implementation of the Federal Public Health Action Plan to Combat Antimicrobial Resistance published in 2001;
• to raise awareness among the media, policymakers and the public about the need for novel federal policy in this area; and  
• to promote the development of an international agenda to limit resistance development globally.

State-Specific Information on Antibiotic Resistance
Working with State Epidemiologists, IDSA has summarized information of the antibacterial drug resistance problem in all 50 U.S. states.
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Policymakers and the public may view IDSA’s statements; relevant reports from the U.S. Public Health Service, General Accounting Office, Institute of Medicine and WHO/UN; and other useful policy documents, resources and links concerning antimicrobial resistance below.

IDSA Statements

New US/EU Transatlantic Task Force on Antimicrobial Resistance and IDSA’s “10 X ’20 Initiative: Two’s Path Forward 12/04/2009
Robert Guidos, JD, IDSA VP, Public Policy & Government Relations, outlines IDSA’s position in an invited guest column of the Center for Global Development’s newsletter.

Summary of Existing Policy on the Use of Antimicrobial Drugs in Food Animals 11/01/2009
IDSA has summarized its existing policies on food animal use of antimicrobials in this one-page fact sheet.

IDSA Testifies to FDA on the Need to Update Susceptibility Breakpoints 10/26/2009
At a recent FDA Anti-Infective Advisory Committee meeting, IDSA testified about its position on updating the Microbiology subsection of product labeling for systemic bacterial drug product labeling and provided recommendations on how FDA could accomplish this task.

IDSA Urges Senate to Boost ID Public Health in Economic Stimulus Plan 01/21/2009
IDSA submitted proposals to Senate leaders urging the stimulus plan include investments in public health infrastructure for infectious diseases. Two proposals emphasize the crises of antimicrobial resistance and emerging infections, and HIV / AIDS and tuberculosis.

IDSA Preliminary Statement on Antibiotic Home Stockpiling 06/18/2008�
At a meeting of the National Biodefense Science Board, IDSA delivered public comments raising concerns about an HHS intiative to inform the public about home stockpiling of doxycycline for use in a potential anthrax attack. 

The Epidemic of Antimicrobial Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America, January 15, 2008 12/12/2007
Published in Clinical Infectious Diseases [CID 2008:46 (15 January)].

IDSA, HIVMA Call for Action on XDR-TB 03/19/2007
A fact sheet details the threat of Extensively Drug-Resistant Tuberculosis (XDR-TB) to the United States and the globe, and outlines urgent federal funding needs for FY08.

View all Statements

IDSA Letters

IDSA Supports FDA’s Preliminary Approach to Breakpoints Updates in a Response to U.S. Rep. DeLauro 11/17/2009
IDSA notes that FDA Appropriations Chairwoman appears to have received some faulty information when she took FDA to task on its plans to update antibacterial breakpoints on drug labeling (e.g., we disagree that the agency is “outsourcing” this essential function to the Clinical Laboratory Standards Institute).

IDSA Urges NIAID Clinical Trial Networks Expansion into New Areas 10/19/2009
NIAID officials are examining the possibility of expanding the Institute’s clinical trials networks to cover tuberculosis, hepatitis C, influenza research. IDSA supports this proposal and has requested that resistant bacterial infections also be considered.

IDSA Urges Obama Administration to Issue and Fund Updated Public Health Action Plan to Combat Antimicrobial Resistance 08/07/2009
In letters to the heads of agencies on the Interagency Task Force on Antimicrobial Resistance, IDSA urges quick issuance of a revised plan, the inclusion of meaningful benchmarks for action items, and funding for the Action Plan to be made a priority for the Administration.

IDSA Proposes Clinical Trials to NIAID That Aim to Improve Antimicrobial Stewardship 07/28/2009
IDSA proposes three, randomized, multi-centered controlled trials to NIAID that seek to optimize antimicrobial prescribing practices.

20 Organizations Support Obama Administration’s New Approach to Drug Approvals and Uses 07/24/2009
IDSA and other organizations applaud the Obama administration and U.S. Food and Drug Administration (FDA) for adopting an approach that demonstrates a clear commitment to sound and science-based polciy development.

IDSA and TFAH Support FDA’s New Thinking on the Use of Antimicrobial Drugs in Animal Agriculture 07/17/2009
On July 13th, FDA testified in support of phasing out the use of antimicrobials in animals for growth promotion/feed efficiency and requiring that all other uses of antimicrobials in animals be carried out under the supervision of a veterinarian and within the boundaries of a valid veterinarian-client-patient relationship. 

View all Letters

IDSA Comments on Federal Agencies’ Actions

Comments on CMS Framework Document ‘8th Quality Improvement Organization Scope of Work’ 01/02/2004
IDSA recommends that CMS include activities to limit the spread of antimicrobial resistance, decrease inappropriate antimicrobial use and improve current infection control in its quality improvement efforts.

Commented on FDA’s Draft Guidance: Evaluating the Safety of Antimicrobial New Animal Drugs with Regard to Their Microbiological Effects on Bacteria on Human Health Concerns 11/01/2002
    See final  FDA’s Guidance announced 10/23/03.

IDSA Supports FDA’s Review of the Use of Antimicrobial Agents in Animals 10/27/2000
Supported FDA’s review of the human health risks associated with the use of antimicroibial agents in animals in a statement. One drug company sponsor, Abbott, has agrreed to withdraw its product. A second company, Bayer, is challenging FDA’s decision. IDSA will continue to monitor this issue.

Comments on PHS Action Plan to Combat Antimicrobial Resistance 08/02/2000
(See the final “Action Plan” (01/18/2001) and follow up “Progress Reports” (06/01/2003) in “General Reports” section below.) 

Institute of Medicine Reports

Microbial Threats to Health: Emergence, Detection, and Response 03/01/2003
IOM report provides a comprehensive study on the policy and infrastructure changes necessary to detect, prevent and respond to microbial threats to health.

Managed Care Systems and Emerging Infections: Challenges and Opportunities for Stregnthening Surveillance, Research, and Prevention, Workshop Summary 12/01/2000
IOM summary is the product of a workshop on how managed care has created both problems and opportunities in the fight against infectious diseases and highlights ways the managed care systems can aid research, develop clinical guidelines, manage the use of antibiotics, support public education efforts and monitor the spread of emerging infections and microbial resistance.

Antimicrobial Resistance: Issues and Options 12/01/1998
IOM summary is the product of a workshop to provide an opportunity for representatives of academia, industry, government and professional groups to examine and discuss scientific and policy dilemmas of common interest that are specifically related to research on and the prevention, detection and management of emerging infections.

Important Links

Antimicrobial (Antibiotic) Resistance
Information from the National Institutes of Allergy and Infectious Diseases

Antibiotic and Antimicrobial Drug Resistance�
Resources from the Centers for Disease Control and Prevention

World Heath Organization (WHO) Global Patient Safety Challenge

World Health Organization (WHO) Global Strategy for Containment of Antimicrobial Resistance 08/01/2001
WHO Report 

View all Important Links

Related Federal Websites

CDC’s Healthcare Infection Control Practices Advisory Committee (HICPAC)

PHS Interagency Task Force on Antimicrobial Resistance (includes federal report: A Public Health Action Plan to Combat Antimicrobial Resistance)

FDA’s Antimicrobial Resistance Webpage

FDA’s Patient Information on Appropriate Antibiotics Usage